Growth differentiation factor 11 promotes macrophage polarization towards M2 to attenuate myocardial infarction via inhibiting Notch1 signaling pathway

Growth differentiation factor 11 promotes macrophage polarization towards M2 to attenuate myocardial infarction via inhibiting Notch1 signaling pathway

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Myocardial infarctions (MI) is a major threat to human health especially in people exposed to cold environment.The polarization of macrophages towards different functional phenotypes (M1 macrophages and M2 macrophages) here is closely related to MI repairment.The growth differentiation factor 11 (GDF11) has been reported to underwater treasures sunken medallion play a momentous role in inflammatory associated diseases.

In this study, we examined the regulatory role of GDF11 in macrophage polarization and elucidated the underlying mechanisms in MI.